Selank
TKPRPGP — Anxiolytic Nootropic Peptide
What is Selank?
Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide Tuftsin. Developed at the Russian Academy of Sciences, it is approved in Russia for treatment of anxiety and cognitive disorders. It is primarily used in the biohacking community as a non-addictive anxiolytic with nootropic properties.
Selank modulates GABA-A receptor activity (similar to benzodiazepines but without dependence risk), increases BDNF and enkephalin levels, and modulates the serotonergic system. It stabilizes the brain's inhibitory-excitatory balance, producing anxiolytic effects without sedation. It also exhibits immunomodulatory properties through the Tuftsin pathway.
Research Evidence
Russian clinical trials demonstrate significant reduction in anxiety symptoms comparable to benzodiazepines without sedation, cognitive impairment, or dependence. Approved in Russia for generalized anxiety disorder.
Studies show improved memory consolidation, learning, and attention. BDNF upregulation provides neuroprotective effects alongside the anxiolytic action.
As a Tuftsin analog, Selank has immunomodulatory properties that may support immune function. Limited controlled data for this application.
Evidence grades: Gold = RCT human data · Silver = multiple animal studies, consistent · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 5 mg | 5 ml | 1 mg/ml | 250mcg = 25 units |
| 10 mg | 10 ml | 1 mg/ml | 500mcg = 50 units |
Frequently Asked Questions
Is Selank addictive?
No. Unlike benzodiazepines, Selank does not appear to create physical dependence or withdrawal. Russian clinical trials and extensive community use have not documented addiction patterns. It modulates GABA-A receptors differently than benzodiazepines, producing anxiolytic effects without tolerance developing rapidly.
Can Selank be combined with Semax?
Yes — Semax + Selank is one of the most popular nootropic stacks. Semax is activating and focus-enhancing. Selank is calming and anxiolytic. Together they produce a balanced cognitive enhancement effect: sharp focus without anxiety, energy without agitation.
How quickly does Selank work?
Intranasal Selank typically produces noticeable anxiolytic effects within 20-40 minutes. The short half-life means effects last 3-5 hours. For longer coverage, twice-daily dosing is common.
References
- [1]Zozulya AA, Neznamov GG, Syunyakov TS, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Bull Exp Biol Med. 2008;146(3):294-298.
- [2]Semenova TP, Kozlovskaya MM, Zuikov AV, et al. Effect of Selank on the content of monoamines and their metabolites in the brain structures of rats. Neurosci Behav Physiol. 2009;39(8):749-752.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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