Peptide Stack Planner
Pre-built protocols graded by evidence quality. Browse the most validated multi-compound stacks, then build your own.
Human clinical trial data or extensive validated clinical use with consistent outcomes
Strong mechanistic evidence + significant community validation or limited human trials
Emerging evidence, compelling mechanism, limited human data — monitor as research develops
Wolverine Protocol
🥇 GoldThe gold-standard tissue repair stack
Compounds
Synergy Mechanism
BPC-157 acts locally at injury sites; TB-500 promotes systemic cell migration and systemic anti-inflammation. Together they cover local + systemic healing simultaneously.
Evidence Note
Extensive animal and human case report data. BPC-157 has 50+ published studies. TB-500 has Phase 2 cardiac data. Most widely validated stack in the peptide community.
GH Pulse Stack
🥇 GoldSynergistic growth hormone optimization
Compounds
Synergy Mechanism
GHRH (CJC-1295) increases the amplitude of GH pulses; GHRP (Ipamorelin) triggers the release. Combined, they work on two separate pathways to maximize the natural GH pulse — without suppressing the hypothalamic-pituitary axis long-term.
Evidence Note
Human clinical trial data shows combining GHRH + GHRP produces synergistic GH release significantly greater than either alone (3-10x greater GH pulse vs. monotherapy). One of the most evidence-backed combinations in peptide therapy.
GLP-1 Defense Stack
🥈 SilverPreserve muscle on GLP-1 therapy
Compounds
Synergy Mechanism
GLP-1 agonists suppress appetite and drive fat loss but can also degrade lean mass. Ipamorelin supports the GH/IGF-1 axis which is critical for muscle protein synthesis, offsetting a key side effect of GLP-1 therapy.
Evidence Note
Mechanism-based evidence + emerging community validation. GLP-1s are known to cause ~25-40% muscle loss alongside fat loss. GH secretagogues help preserve lean mass. No completed RCT for this specific combination, but growing clinical adoption.
Cognitive Foundation
🥈 SilverCalm focus and neuroprotection
Compounds
Synergy Mechanism
Selank reduces anxiety and stress reactivity; Semax enhances BDNF and cognitive processing speed. The combination produces anxiolysis without sedation, paired with cognitive enhancement. Both are intranasal — convenient same-dose administration.
Evidence Note
Both have Russian clinical trial data. Selank has Phase 2/3 data for generalized anxiety disorder. Semax has neurological research for stroke recovery and cognitive enhancement. Both approved as drugs in Russia. Limited US human trials, but mechanisms well-understood.
Longevity Triad
🥈 SilverMulti-pathway anti-aging protocol
Compounds
Synergy Mechanism
Epithalon targets telomere length (upstream aging clock); GHK-Cu activates wound-repair and anti-inflammatory gene programs; NAD+ restores mitochondrial energy metabolism. Each targets a distinct aging pathway.
Evidence Note
Epithalon has Khavinson Institute human data showing telomere effects. GHK-Cu has 50+ published studies on collagen and gene expression. NAD+ IV/SubQ has growing clinical evidence. No combined human RCT, but individually each is well-supported.
Skin & Collagen Stack
🥈 SilverInjectable aesthetics from the inside
Compounds
Synergy Mechanism
Both upregulate collagen synthesis via different mechanisms: GHK-Cu activates copper-dependent prolyl hydroxylase; BPC-157 upregulates VEGF and growth factor pathways. Can be combined in the same injection for convenience.
Evidence Note
GHK-Cu has 50+ human studies on skin and wound healing. BPC-157 has wound healing studies in animal models and case reports in humans. Combined collagen synthesis effect is additive based on mechanism.
Metabolic Edge
🥉 BronzeMitochondrial efficiency meets fat metabolism
Compounds
Synergy Mechanism
MOTS-c activates AMPK pathways that mimic exercise at the cellular level; AOD-9604 targets the beta-3 adrenergic receptor pathway for selective fat burning. Different mechanisms targeting fat metabolism from complementary angles.
Evidence Note
MOTS-c has strong animal data and emerging human data for metabolic effects. AOD-9604 has human obesity trials (Metabolic). Combination is mechanistically logical but no combined RCT data exists. Bronze grade reflects limited but promising evidence.
Immune Foundation
🥈 SilverImmune modulation and systemic healing
Compounds
Synergy Mechanism
TA-1 modulates the adaptive immune response (T-helper cell regulation); BPC-157 supports gut mucosal integrity which is central to immune function (70% of immune system is gut-associated). Foundational combination for any immune disorder or autoimmune protocol.
Evidence Note
TA-1 (Zadaxin) has extensive human clinical trial data for immune conditions including hepatitis and cancer immunotherapy support. BPC-157 has strong gut healing data. Combination provides immune regulation + gut health simultaneously.
Build a Custom Stack
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How to Choose a Peptide Stack
The most effective peptide stacks combine compounds that work through complementary mechanisms rather than redundant pathways. Gold-grade stacks like the GH Pulse Stack (CJC-1295 + Ipamorelin) have human clinical trial data demonstrating their synergistic effect — the combination produces 3–10x greater GH release than either compound alone because they target different receptors in the GH secretion pathway.
Silver-grade stacks are mechanistically compelling with community validation but lack combined RCT data. The Wolverine Protocol (BPC-157 + TB-500) is in this category — each compound has substantial research individually, and the combination is the most widely used repair stack in the peptide community, but a combined human trial has not been completed.
Bronze-grade stacks are emerging protocols with limited but promising evidence. They represent areas where the mechanism is well-understood but human data is early. These should be approached with additional caution and monitoring.