N-Acetyl Selank
NA-Selank — Acetylated Selank Analog
What is N-Acetyl Selank?
N-Acetyl Selank (NA-Selank) is a modified version of Selank with an N-acetyl group added to the N-terminus, increasing resistance to enzymatic degradation. Like NA-Semax, the acetylation extends the active half-life compared to standard Selank and may enhance CNS penetration via the intranasal route. NA-Selank is used as an anxiolytic nootropic with potentially longer duration than standard Selank.
NA-Selank retains Selank's GABA-A modulation, BDNF upregulation, and serotonergic activity while the acetyl group reduces aminopeptidase-mediated degradation. This translates to a longer duration of anxiolytic effect per dose. The Tuftsin-derived immunomodulatory activity is also retained. The acetylation changes the peptide's physicochemical properties in ways that may improve nasal membrane permeation.
Research Evidence
The N-acetyl modification is established to increase peptide stability. Community use reports consistently describe longer anxiolytic effect duration vs standard Selank, supporting the stability hypothesis.
The base anxiolytic and cognitive mechanisms (GABA-A modulation, BDNF upregulation) are the same as standard Selank. No controlled trial data specific to NA-Selank.
Evidence grades: Gold = RCT human data · Silver = consistent animal/human data · Bronze = limited or preliminary
Dosing Protocols
Reconstitution / Preparation
| Vial | Diluent | Concentration | Draw |
|---|---|---|---|
| 5 mg | 5 ml | 1 mg/ml | 250mcg = 25 units |
| 10 mg | 10 ml | 1 mg/ml | 500mcg = 50 units |
Frequently Asked Questions
Is NA-Selank more effective than standard Selank?
For users who find standard Selank's duration too short, NA-Selank may be preferred due to its longer-acting profile from greater enzymatic stability. Whether the base anxiolytic efficacy is stronger is unclear — the mechanism is identical. Personal preference based on desired duration typically determines which form is used.
Can NA-Selank be used for social anxiety?
Yes. NA-Selank's anxiolytic mechanism (GABA-A modulation without sedation) makes it suitable for situational social anxiety. The longer duration of NA-Selank may be advantageous for extended social situations compared to standard Selank.
References
- [1]Zozulya AA, Neznamov GG, Syunyakov TS, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders. Bull Exp Biol Med. 2008;146(3):294-298.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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