KPV
Lysine-Proline-Valine — Alpha-MSH C-terminal Tripeptide
What is KPV?
KPV is a tripeptide (Lysine-Proline-Valine) derived from the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It retains the anti-inflammatory properties of alpha-MSH without the melanotropic effects of the full peptide. Primarily studied for inflammatory bowel disease, gut healing, and skin inflammation.
KPV inhibits the NF-kB signaling pathway — a master regulator of inflammatory gene expression. It directly enters immune cells and gut epithelial cells to suppress inflammatory cytokine production. Its small tripeptide structure allows oral bioavailability and direct gastrointestinal tissue penetration.
Research Evidence
Multiple animal studies demonstrate significant reduction in colitis symptoms, mucosal healing, and inflammatory cytokine reduction. Often stacked with BPC-157 for complementary gut healing mechanisms.
Topical KPV shows efficacy in psoriasis and dermatitis models through local NF-kB inhibition.
SubQ administration produces systemic anti-inflammatory effects. Community protocols use KPV alongside BPC-157 for comprehensive gut and systemic healing.
Evidence grades: Gold = RCT human data · Silver = multiple animal studies, consistent · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 10 mg | 2 ml | 5 mg/ml | 300mcg = 6 units |
| 10 mg | 5 ml | 2 mg/ml | 300mcg = 15 units |
Frequently Asked Questions
What is KPV used for?
KPV is primarily used for inflammatory bowel disease, colitis, leaky gut, and skin inflammation. Often stacked with BPC-157 for gut healing — BPC-157 promotes tissue healing through VEGF while KPV directly suppresses the NF-kB inflammatory signaling.
Can KPV be taken orally?
Yes — and oral is often the preferred route for gut applications. KPV's tripeptide structure makes it more resistant to gastric acid degradation than larger peptides. Unlike most injectable peptides, KPV has meaningful oral bioavailability for gut-targeted use.
References
- [1]Brzoska T, Luger TA, Maaser C, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects. Endocr Rev. 2008;29(5):581-602.
- [2]Kannengiesser K, Maaser C, Heidemann J, et al. Melanocyte-stimulating hormone peptides promote intestinal epithelial wound healing in vitro and in vivo. Regul Pept. 2008;151(1-3):33-38.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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