BPC-157
Body Protection Compound-157
What is BPC-157?
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a protective protein naturally found in human gastric juice. It is not a hormone or a naturally circulating peptide at physiological levels — it is a stable, synthetic research compound with documented effects on wound healing, tissue repair, and gastrointestinal protection in preclinical models.
Its primary mechanism involves modulation of growth hormone receptors, upregulation of VEGF (vascular endothelial growth factor) to promote angiogenesis, and interaction with the nitric oxide system. BPC-157 appears to accelerate the formation of new blood vessels at injury sites and stimulate tendon fibroblast activity, which explains its observed effects on tendon and ligament healing in animal studies.
The “body protection” designation reflects its gastroprotective properties: BPC-157 has been studied for its ability to counteract NSAID-induced stomach damage, heal intestinal anastomoses, and repair fistulas — effects consistent with a locally-acting cytoprotective agent.
Research Evidence
Multiple rat models demonstrate accelerated Achilles tendon repair, superior collagen organization, and increased tensile strength vs. controls. Effect sizes are large but translation to humans is unconfirmed.
Strong preclinical data for protection against NSAID-induced ulcers, healing of intestinal fistulas, and repair of IBD-like bowel damage. Oral and systemic administration both show effects.
Rat models show improved healing of crush injuries and improved muscle reattachment after transection. Limited data, promising direction.
Modest preclinical data suggesting BPC-157 may have neuroprotective effects after traumatic brain injury and dopamine system modulation. Highly exploratory.
Evidence grades: Gold = RCT human data · Silver = multiple animal studies, consistent · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
BPC-157 is supplied as a lyophilized white powder requiring reconstitution with bacteriostatic water (BAC water) before injection. Do not use plain sterile water — BAC water contains benzyl alcohol which prevents bacterial growth and extends shelf life after reconstitution.
| Vial Size | BAC Water | Concentration | 250 mcg draw |
|---|---|---|---|
| 2 mg | 1 ml | 2,000 mcg/ml | 12.5 units (0.125 ml) |
| 5 mg | 2 ml | 2,500 mcg/ml | 10 units (0.10 ml) |
| 5 mg | 5 ml | 1,000 mcg/ml | 25 units (0.25 ml) |
| 10 mg | 4 ml | 2,500 mcg/ml | 10 units (0.10 ml) |
Frequently Asked Questions
What is BPC-157 used for?
BPC-157 is researched for tissue repair, tendon and ligament healing, gut protection, and wound healing. It is not FDA-approved for human use but is widely studied in preclinical models with promising results for injury recovery applications.
What is the typical BPC-157 dosing protocol?
Research protocols typically use 250–500 mcg per day injected subcutaneously or intramuscularly near the injury site. Some protocols split into twice-daily injections of 200–250 mcg. Oral administration of 500 mcg–1 mg is used for gut-related applications.
Is BPC-157 legal in 2026?
BPC-157 is currently FDA Category 2, meaning it cannot be compounded by 503A pharmacies. The FDA PCAC is scheduled to review BPC-157 on July 23, 2026 for potential reclassification to Category 1. See our full regulatory status article for details.
How do you store reconstituted BPC-157?
Once reconstituted, store in the refrigerator at 2–8°C. Protect from light. Reconstituted BPC-157 in BAC water is typically stable for 4–6 weeks refrigerated. Lyophilized powder should be stored frozen until ready to use.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.