Cortagen
Ala-Glu-Asp-Pro — Cerebral Cortex Peptide Bioregulator
What is Cortagen?
Cortagen is a tetrapeptide (Ala-Glu-Asp-Pro, AEDP) derived from cerebral cortex tissue — another Khavinson peptide bioregulator developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is proposed to have tissue-specific regulatory activity on cerebral cortex cells, promoting neuronal survival, repair, and function particularly in the context of aging and injury.
Like other Khavinson peptides, Cortagen is proposed to penetrate cell nuclei and interact with regulatory DNA sequences to modulate gene expression in cortical neurons. Russian research suggests it upregulates heat shock proteins, reduces neuronal apoptosis, enhances antioxidant defenses in cortical tissue, and may promote functional recovery after brain injury. The mechanism is proposed to be epigenetic rather than receptor-mediated.
Research Evidence
Russian in vitro and animal studies demonstrate Cortagen reduces neuronal apoptosis in cortical cells and improves antioxidant defense mechanisms. Animal stroke models show reduced infarct volume.
Limited to Russian clinical reports of improved outcomes in stroke rehabilitation and cognitive decline. No Western independent replication.
Evidence grades: Gold = RCT human data · Silver = consistent animal/human data · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 10 mg | 2 ml | 5 mg/ml | 5mg = 10 units |
| 20 mg | 4 ml | 5 mg/ml | 5mg = 10 units |
Frequently Asked Questions
What is Cortagen used for?
Cortagen is used in Russian-inspired biohacking protocols for brain aging, cognitive decline prevention, and neurological recovery. It is part of the Khavinson peptide bioregulator system alongside Epithalon (pineal/longevity), Thymalin (immune), and Pinealon (neuroprotection). Community use is limited compared to the other Khavinson peptides due to less available information in English.
How does Cortagen compare to Semax or Dihexa?
Cortagen is proposed to work through epigenetic gene regulation in cortical neurons (Khavinson mechanism). Semax works through BDNF/NGF upregulation and dopaminergic modulation. Dihexa works through HGF/MET receptor synaptogenesis. Three distinct mechanisms — some longevity protocols combine all three for comprehensive neuroprotection through different pathways.
References
- [1]Khavinson VK, Lezhava TA, Monaselidze JR, et al. Peptide Ala-Glu-Asp-Gly has effect on gene expression and protein synthesis in human neuronal cells during aging. Neuro Endocrinol Lett. 2003;24(3-4):188-192.
- [2]Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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