Pinealon
EDR Peptide — Pineal Gland Neuropeptide
What is Pinealon?
Pinealon is a tripeptide (Glu-Asp-Arg, EDR) developed by Russian researcher Vladimir Khavinson — the same researcher behind Epithalon. It is derived from the pineal gland and is proposed to have neuroprotective and cognitive-enhancing properties. Like Epithalon, it has been studied within the Russian bioregulation framework as a tissue-specific peptide bioregulator.
Pinealon is proposed to act as a gene expression modulator — penetrating cell nuclei and directly influencing transcription of neuroprotective genes. Russian research suggests it upregulates antioxidant defense enzymes, reduces neuronal apoptosis, and protects against hypoxia-induced neuronal death. It is postulated to work through interaction with regulatory DNA sequences, similar to the mechanism proposed for other Khavinson peptides.
Research Evidence
Russian in vitro and animal studies demonstrate Pinealon reduces neuronal apoptosis under hypoxic conditions and increases expression of antioxidant genes.
Community reports of improved sleep quality and cognitive clarity. Plausible via pineal peptide mechanism and melatonin axis modulation. Limited independent human data.
Evidence grades: Gold = RCT human data · Silver = consistent animal/human data · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 10 mg | 2 ml | 5 mg/ml | 5mg = 10 units |
| 10 mg | 1 ml | 10 mg/ml | 5mg = 5 units |
Frequently Asked Questions
Is Pinealon the same as Epithalon?
No. Both are Khavinson peptides derived from the pineal gland but are different molecules. Epithalon (tetrapeptide AEDG) primarily targets telomerase and telomere elongation. Pinealon (tripeptide EDR) primarily targets neuronal protection and gene expression regulation. They are sometimes stacked together in Russian-inspired longevity protocols.
Is there human clinical trial data for Pinealon?
Published English-language human trials are limited. Most research originates from Russian institutions under Khavinson's research program. The evidence base is more limited than Epithalon and primarily consists of in vitro and animal studies. Community use is based on the mechanistic plausibility and the broader Khavinson research framework.
References
- [1]Khavinson VKh, Lezhava TA, Monaselidze JR, et al. Peptide Ala-Glu-Asp-Gly has effect on gene expression and protein synthesis in human neuronal cells during aging. Neuro Endocrinol Lett. 2003;24(3-4):188-192.
- [2]Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cells. Bull Exp Biol Med. 2004;137(5):503-506.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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