Research/Compounds/CJC-1295 + Ipamorelin Blend
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CJC-1295 + Ipamorelin Blend

GHRH + GHRP Growth Hormone Secretagogue Stack

Half-life
CJC: 7-8d / Ipa: 2h
Route
SC
Typical dose
100-300mcg each
Timing
Fasted / pre-sleep

Blend Composition

CJC-1295 No DAC
—
GHRH
Growth hormone releasing hormone analog — stimulates pituitary GH release
Ipamorelin
—
GHRP
GH releasing peptide — mimics ghrelin, potentiates GH pulse

What is CJC-1295 + Ipamorelin Blend?

The CJC-1295 + Ipamorelin blend is the most widely used growth hormone secretagogue stack. It combines a GHRH analog (CJC-1295 No DAC) with a GHRP (Ipamorelin) to create a synergistic, dual-mechanism stimulus for pituitary GH release — producing a larger GH pulse than either compound alone.

CJC-1295 No DAC (also called Mod GRF 1-29) mimics growth hormone releasing hormone, signaling the pituitary to release GH. Ipamorelin mimics ghrelin and acts on a separate receptor pathway to amplify the GH pulse. The combination produces GH release that is both stronger and more physiologically timed than either compound independently.

This blend is distinct from CJC-1295 with DAC, which has a much longer half-life due to the Drug Affinity Complex modification and produces continuous GH elevation rather than pulsatile release. The No DAC version preserves the natural pulsatile pattern, which is generally preferred in optimization protocols.

Reconstitution

Typically sold as individual vials (CJC-1295 No DAC 2mg and Ipamorelin 2mg or 5mg each) or as a pre-mixed blend vial. For a pre-mixed 10mg blend (5mg each): add 2mL BAC water for 5mg/mL concentration. At 10 units: 500mcg total (250mcg each compound).

Use the Reconstitution Calculator for exact amounts.

FAQ

What is the CJC-1295 + Ipamorelin blend?+
A combination of CJC-1295 No DAC (a GHRH analog) and Ipamorelin (a GHRP) that together produce a synergistic growth hormone pulse from the pituitary. It is the most popular GH secretagogue stack for anti-aging, body composition, and recovery protocols.
When should I inject CJC-1295 + Ipamorelin?+
Most protocols use injection 30-60 minutes before sleep or in a fasted state (at least 90 minutes post-meal). Insulin and elevated blood glucose blunt GH release. Pre-sleep dosing takes advantage of the natural nocturnal GH surge.
What is the difference between CJC-1295 No DAC and CJC-1295 with DAC?+
CJC-1295 No DAC has a half-life of approximately 30 minutes, producing a pulsatile GH release pattern that mirrors natural GH secretion. CJC-1295 with DAC binds to albumin, extending half-life to 6-8 days and producing continuous GH elevation. Most optimization protocols prefer No DAC for its physiological pulse pattern.
How does Ipamorelin differ from other GHRPs?+
Ipamorelin is highly selective for GH release with minimal effect on cortisol, prolactin, and ACTH — unlike GHRP-2 and GHRP-6, which produce broader hormonal effects. This selectivity makes Ipamorelin the preferred GHRP for most protocols.

Related Compounds

CJC-1295IpamorelinSermorelinTesamorelin

For educational and research purposes only. Not medical advice.