CJC-1295
Modified GRF 1-29 · Growth Hormone Releasing Hormone Analog
What is CJC-1295?
CJC-1295 is a modified version of the first 29 amino acids of natural GHRH (Modified GRF 1-29). It stimulates pituitary somatotroph cells to release growth hormone in response to natural GH pulses. Unlike GHRH itself (which degrades in seconds), CJC-1295 contains substitutions that prevent enzymatic degradation and extend the half-life to ~30 minutes for the no-DAC version.
The DAC version adds a Drug Affinity Complex that covalently bonds to albumin, extending the half-life to 7–8 days. Most anti-aging physicians prefer no-DAC (Modified GRF 1-29) for preserving natural GH rhythms.
No-DAC vs DAC
No-DAC (Modified GRF 1-29) ✓ Preferred
- •~30 min half-life
- •Inject with GHRP for pulsatile GH
- •Mimics natural GHRH rhythm
- •2–3x/day dosing
- •Better for GH optimization
DAC Version
- •~7–8 day half-life
- •1–2x/week dosing
- •Sustained IGF-1 elevation
- •Blunts natural GH pulsatility
- •Better for IGF-1 focused protocols
Dosing
Frequently Asked Questions
What is CJC-1295?
A GHRH analog that stimulates pulsatile GH release from the pituitary. Works synergistically with GHRPs. Category 1 — available by prescription.
No-DAC vs DAC — which should I use?
No-DAC for most protocols — preserves natural GH pulsatility, injected 2-3x/day with ipamorelin. DAC for simplified once-weekly dosing and sustained IGF-1 elevation.
Is CJC-1295 legal?
Category 1. Legally available through licensed 503A compounding pharmacies with a valid prescription.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.