5-Amino-1MQ
5-Amino-1-methylquinolinium — NNMT Inhibitor
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase) — an enzyme that consumes SAM and reduces NAD+ precursor availability while driving fat cell expansion. By inhibiting NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1 and other sirtuins, and reverses metabolic changes that drive fat cell differentiation and obesity.
NNMT is highly expressed in white adipose tissue and upregulated in obesity. Its inhibition raises intracellular NAD+ and SAM levels, activates SIRT1, reduces fat cell size and differentiation, and increases metabolic rate without stimulant effects. The mechanism is distinct from GLP-1 (appetite suppression), AMPK activation (MOTS-c), and fat receptor agonism (AOD-9604).
Research Evidence
Preclinical studies show significant reduction in fat cell size and adipogenesis inhibition in mice on high-fat diet. Mechanism is well-characterized at the cellular level.
Demonstrated NAD+ elevation and SIRT1 activation in cell and animal models — linking it to longevity pathways alongside metabolic effects.
Rapidly growing community use with consistent anecdotal fat loss and energy reports. No published human RCTs. $7.72 CPC reflects strong commercial and research interest.
Evidence grades: Gold = RCT human data · Silver = consistent animal/human data · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
This compound does not require reconstitution — it is available as a pre-mixed injectable or oral formulation.
Frequently Asked Questions
What does 5-Amino-1MQ do?
5-Amino-1MQ inhibits NNMT, an enzyme that consumes NAD+ precursors and drives fat cell expansion. Inhibiting NNMT raises intracellular NAD+, activates sirtuins, reduces fat cell differentiation, and increases metabolic rate — without stimulant effects. The mechanism is distinct from GLP-1 drugs and traditional fat burners.
Is 5-Amino-1MQ the same as NMN or NR?
No, though complementary. NMN and NR are NAD+ precursors that increase supply. 5-Amino-1MQ inhibits NNMT which consumes NAD+ precursors — preventing them from being wasted. Together they address both sides of the NAD+ equation: more supply (NMN/NR) and less consumption (5-Amino-1MQ).
References
- [1]Neelakantan H, Wang HY, Vance V, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492.
- [2]Kannt A, Rajagopal S, Kadnur SV, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018;8(1):3660.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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