Kisspeptin-10
KISS1(112-121) — GnRH Stimulator & Reproductive Neuropeptide
What is Kisspeptin-10?
Kisspeptin-10 is the shortest active fragment of kisspeptin — a neuropeptide encoded by the KISS1 gene that acts as the master regulator of the HPG (hypothalamic-pituitary-gonadal) axis. It directly stimulates GnRH neurons in the hypothalamus to produce pulsatile GnRH release, which drives LH and FSH secretion and downstream sex hormone production.
Kisspeptin-10 binds to the KiSS1 receptor (GPR54) on hypothalamic GnRH neurons, triggering GnRH pulse generation. This positions Kisspeptin upstream of GnRH in the reproductive axis — making it the most fundamental hormonal intervention possible for HPG axis optimization. It also plays roles in metabolic signaling, mood, and olfactory-driven sexual behavior through kisspeptin neurons in the brain.
Research Evidence
Multiple human Phase 1/2 trials confirm kisspeptin-10 infusion produces robust dose-dependent LH pulses. Well-characterized pharmacology in healthy men and women.
Clinical studies show kisspeptin can restore LH pulsatility in hypothalamic hypogonadism — potentially the most upstream intervention available for this condition.
Human studies suggest kisspeptin modulates sexual attraction, mood, and emotional brain processing. Potential applications in low libido and sexual dysfunction beyond direct hormonal effects.
Evidence grades: Gold = RCT human data · Silver = consistent animal/human data · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 5 mg | 5 ml | 1 mg/ml | 100mcg = 10 units |
| 10 mg | 10 ml | 1 mg/ml | 100mcg = 10 units |
Frequently Asked Questions
How does Kisspeptin differ from Gonadorelin?
Both stimulate GnRH output but at different levels of the axis. Gonadorelin IS GnRH — it acts directly at the pituitary. Kisspeptin-10 acts one step upstream — it stimulates hypothalamic GnRH neurons to produce GnRH. Kisspeptin is the most upstream hormonal intervention for HPG axis stimulation. Gonadorelin bypasses the hypothalamus; Kisspeptin activates it.
Why must Kisspeptin be dosed in pulses?
The same paradox as GnRH agonists applies: continuous stimulation of GPR54 receptors causes downregulation and HPG axis suppression rather than stimulation. This is how GnRH agonists (Lupron, etc.) suppress testosterone — through continuous receptor activation. Pulsatile or infrequent Kisspeptin administration stimulates GnRH release; continuous administration suppresses it.
References
- [1]Dhillo WS, Chaudhri OB, Patterson M, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
- [2]Jayasena CN, Nijher GM, Abbara A, et al. Twice-weekly kisspeptin-54 for 8 weeks stimulates release of LH and sex steroids in women with hypothalamic amenorrhea. Clin Pharmacol Ther. 2010;88(6):840-847.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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