GHRP-2
Growth Hormone Releasing Peptide-2
What is GHRP-2?
GHRP-2 is a synthetic hexapeptide that stimulates GH release through ghrelin receptor activation. More selective than GHRP-6 but less selective than Ipamorelin, it produces significant GH pulses with moderate cortisol and prolactin elevation and minimal appetite stimulation.
GHRP-2 activates GHS-R1a in the pituitary and hypothalamus producing a strong GH pulse. It acts synergistically with GHRH analogs (Sermorelin, CJC-1295) to amplify GH pulse amplitude. Its moderate appetite stimulation (less than GHRP-6) makes it more suitable for fat loss protocols than GHRP-6.
Research Evidence
Multiple clinical studies confirm robust GH release with a strong dose-response relationship. GHRP-2 is among the most studied GHRPs in controlled human trials.
Clinical use in adult GH deficiency shows improvements in lean body mass and fat distribution consistent with GH elevation.
Community protocols use GHRP-2 for recovery, sleep quality, and anti-aging. Plausible through GH/IGF-1 elevation.
Evidence grades: Gold = RCT human data · Silver = multiple animal studies, consistent · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 2 mg | 2 ml | 1 mg/ml | 100mcg = 10 units |
| 5 mg | 5 ml | 1 mg/ml | 100mcg = 10 units |
Frequently Asked Questions
How does GHRP-2 compare to Ipamorelin?
Both stimulate GH through the ghrelin receptor. Ipamorelin is more selective — it does not raise cortisol or prolactin at standard doses. GHRP-2 does elevate both moderately. Ipamorelin is preferred when cortisol management matters. GHRP-2 may produce slightly stronger GH pulses.
Can GHRP-2 be mixed with CJC-1295 in the same syringe?
Yes. GHRP-2 and CJC-1295 (no DAC) are the most commonly mixed peptide combination. Both stored in bacteriostatic water. Draw CJC-1295 first, then GHRP-2. This combination produces synergistic GH release.
References
- [1]Arvat E, Gianotti L, Grottoli S, et al. Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects. J Clin Endocrinol Metab. 1994;79(5):1440-1443.
- [2]Sigalos JT, Pastuszak AW. The safety and efficacy of growth hormone secretagogues. Sex Med Rev. 2018;6(1):45-53.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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