GHK-Cu
Copper Peptide — Glycine-Histidine-Lysine Copper
What is GHK-Cu?
GHK-Cu (Glycine-Histidine-Lysine-Copper) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Plasma concentrations decline significantly with age. It plays a central role in wound healing, collagen synthesis, and tissue remodeling, with among the strongest evidence bases of any cosmetic peptide.
GHK-Cu activates collagen synthesis by stimulating collagen types I, III, and VI production in fibroblasts. It promotes angiogenesis, exhibits anti-inflammatory and antioxidant activity, and has a unique dual ability to break down damaged collagen and stimulate new collagen formation simultaneously.
Research Evidence
Multiple controlled trials demonstrate accelerated wound closure, improved tensile strength, and enhanced angiogenesis. Topical formulations have the strongest evidence base.
Clinical studies show reduction in fine lines and improved skin elasticity with consistent topical use. One of the most evidence-backed anti-aging peptides in cosmetic dermatology.
Used in GLP-1 weight loss protocols to mitigate loose skin. GHK-Cu stimulates collagen and elastin to compensate for skin changes during rapid fat loss.
Evidence grades: Gold = RCT human data · Silver = multiple animal studies, consistent · Bronze = limited or preliminary
Dosing Protocols
Reconstitution Guide
| Vial Size | BAC Water | Concentration | Target draw |
|---|---|---|---|
| 50 mg | 5 ml | 10 mg/ml | 1mg = 10 units |
| 50 mg | 10 ml | 5 mg/ml | 1mg = 20 units |
Frequently Asked Questions
What is GHK-Cu used for?
GHK-Cu is used for wound healing acceleration, skin anti-aging and collagen stimulation, hair follicle stimulation, and as a supportive peptide during rapid fat loss to maintain skin elasticity.
Is topical or injectable GHK-Cu better?
Depends on the application. Topical has the strongest clinical evidence for skin concerns. Injectable SubQ allows broader systemic distribution. Many protocols use both simultaneously.
References
- [1]Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108.
- [2]Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987.
This profile was prepared using AI-assisted research synthesis. Citations are provided where applicable — verify with primary sources before clinical application.
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